Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
a binary complex with UDP and a ternary complex with UDP and peptide substrate YPGGSTPVSSANMM, hanging drop vapor diffusion method | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel affinity chromatography and gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-GlcNAc + YPGGSTPVSSANMM | - |
Homo sapiens | UDP + YPGGSTPVS-3-O-(N-acetyl-D-glucosaminyl)-SANMM | - |
? |
Synonyms | Comment | Organism |
---|---|---|
O-GlcNAc transferase | - |
Homo sapiens |
OGT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | aberrant OGlcNAcylation by the enzyme is linked to insulin resistance, diabetic complications, cancer and neurodegenerative diseases including Alzheimer's disease | Homo sapiens |