Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
cDNA encoding IGnT is cloned from PA-1 cells, 400-amino acids protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | type II transmembrane topology | Mus musculus | 16020 | - |
membrane | type II transmembrane topology | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
cIGnT, purified from PA-1 cells | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | IGnT is highly expressed in adult cerebellum and the frontal lobe of adult brain, also expression in fetal brain | Homo sapiens | - |
cerebellum | IGnT is highly expressed in adult cerebellum | Homo sapiens | - |
colon | IGnT is moderately expressed in adult colon | Homo sapiens | - |
gastric mucosa | dIGnT | Sus scrofa | - |
heart | IGnT is moderately expressed in adult heart | Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | IGnT expression in fetal kidney | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | cIGnT | Rattus norvegicus | - |
lung | IGnT expression in fetal lung | Homo sapiens | - |
PA-1 cell | tetracarcinoma cells, IGnT mainly acts as cIGnT, but can also act as dIGnT with 6-30% of the activity of cIGnT | Homo sapiens | - |
prostate gland | IGnT is highly expressed in adult prostata | Homo sapiens | - |
small intestine | IGnT is moderately expressed in adult small intestine | Homo sapiens | - |
small intestine | cIGnT is the dominant form | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Mus musculus | ? | - |
? | |
additional information | 2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues | Homo sapiens | ? | - |
? | |
additional information | 2 types of branching enzyme activities: cIGnT6 generates beta-1,6-N-acetylglucosaminyl branches at the central galactose residue, and dIGnT6 acts on peridistal galactose residues | Sus scrofa | ? | - |
? | |
additional information | expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-3)GalNAcalpha1-R | dIGnT | Sus scrofa | UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-3)GalNAcalpha1-R | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-4)Glc | dIGnT | Sus scrofa | UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta(1-3)Galbeta(1-4)Glc(NAc)beta1-R | dIGnT | Sus scrofa | UDP + GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc(NAc)beta1-R | - |
? | |
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | - |
Mus musculus | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | - |
Sus scrofa | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | transfer of GlcNAc to beta1,4-linked Gal residue in a linear poly-N-acetyllactosamine with the approximate structure Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc(NAc)-R, forming Galbeta(1-4)GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc(NAc)-R | Homo sapiens | ? | - |
? |