Cloned (Comment) | Organism |
---|---|
2 isoforms IGnT A and IGnT B are produced by alternative splicing of the IGnT gene, the C-terminal 1/4 of IGnT B is identical to that of IGnT A | Mus musculus |
expression of each isoform is controlled by a different promoter, characterization of the promoters: GT boxes play crucial roles in transcriptional regulation of the genes | Mus musculus |
IGnT A is cloned | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation experiments at the GT boxes of the promoters of IGnT A and B genes | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | Mus musculus | forms branches in poly-N-acetyllactosamines, which bear the I blood group antigen | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
F9 cell | F9 embryonal carcinoma cells moderately express IGnT A and B | Mus musculus | - |
intestine | strong expression of IGnT A and B in adults | Mus musculus | - |
kidney | strong expression of IGnT A and B in adults | Mus musculus | - |
liver | strong expression of IGnT A and B in adults | Mus musculus | - |
mammary gland | moderate expression of IGnT A and B | Mus musculus | - |
additional information | no expression of IGnT A and B in N2a cells | Mus musculus | - |
submaxillary gland | moderate expression of IGnT A and B | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | 2 isoforms IGnT A and IGnT B, C-terminal 1/4 of IGnT B is identical to that of IGnT A, the rest of the sequences shows 63% identity | Mus musculus | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | forms branches in poly-N-acetyllactosamines | Mus musculus | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine | forms branches in poly-N-acetyllactosamines, which bear the I blood group antigen | Mus musculus | ? | - |
? |