Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin fibroblast | from an Ehlers-Danlos syndrome patient carrying the C808T mutation in the beta4GalT-7 gene, and skin fibroblasts from a healthy age-matched donor. The reduction in galactosyltransferase activity caused by the R270C substitution in beta4GalT-7 leads to a reduction in the sulfation degree of heparan sulfate. The structural alterations, which were particularly prominent for cell-associated heparan sulfate, are paralleled by significantly delayed wound closure in vitro, increased adhesion to fibronectin, a reduced capability to form actin stress fibers, filopodia and collagen gel-contracting forces | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
beta4-galactosyltransferase 7 | - |
Homo sapiens |
beta4GalT-7 | - |
Homo sapiens |