Literature summary for 2.3.3.5 extracted from

Zhang, Y.; Zhou, X.; Wang, X.; Wang, L.; Xia, M.; Luo, J.; Shen, Y.; Wang, M.
Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum (2020), Microb. Cell Fact., 19, 13 .

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Application

Application	Comment	Organism
drug development	androstenedione is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of androstenedione is mainly the degradation of the phytosterol aliphatic side chain, which is accompanied by the production of propionyl CoA. Excessive accumulation of intracellular propionyl-CoA produces a toxic effect in mycobacteria, which restricts the improvement of production efficiency. Biotransformation at low nitrogen levels can be improved by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum	Mycolicibacterium neoaurum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
propanoyl-CoA + H2O + oxaloacetate	Mycolicibacterium neoaurum	the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria	(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium neoaurum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
propanoyl-CoA + H2O + oxaloacetate	-	Mycolicibacterium neoaurum	(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA	-	?
propanoyl-CoA + H2O + oxaloacetate	the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria	Mycolicibacterium neoaurum	(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA	-	?

Synonyms

Synonyms	Comment	Organism
Methylcitrate synthase	-	Mycolicibacterium neoaurum
PrpC	-	Mycolicibacterium neoaurum

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria	Mycolicibacterium neoaurum

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Release 2023.1 (January 2023)