Literature summary for 2.3.3.21 extracted from

Wu, B.; Zhang, B.; Feng, X.; Rubens, J.; Huang, R.; Hicks, L.; Pakrasi, H.; Tang, Y.
Alternative isoleucine synthesis pathway in cyanobacterial species (2010), Microbiology, 156, 596-602.

Search for more literature for 2.3.3.21

Application

Application	Comment	Organism
synthesis	the autrotrophic micro-organism may be engineered for robust butanol and propanol production from 2-ketobutyrate, which is an intermediate in the isoleucine biosynthesis pathway	Crocosphaera subtropica ATCC 51142

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + pyruvate + H2O	Crocosphaera subtropica ATCC 51142	-	CoA + (2R)-2-hydroxy-2-methylbutanedioate	-	?

Organism

Organism	UniProt	Comment	Textmining
Crocosphaera subtropica ATCC 51142	-	an aerobic unicellular marine cyanobacterium, gene cimA	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + pyruvate + H2O	-	Crocosphaera subtropica ATCC 51142	CoA + (2R)-2-hydroxy-2-methylbutanedioate	-	?
acetyl-CoA + pyruvate + H2O	-	Crocosphaera subtropica ATCC 51142	CoA + (2R)-2-hydroxy-2-methylbutanedioate	i.e. (-)-citramalate	?

Synonyms

Synonyms	Comment	Organism
CimA	-	Crocosphaera subtropica ATCC 51142
citramalate synthase	-	Crocosphaera subtropica ATCC 51142

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Crocosphaera subtropica ATCC 51142

General Information

General Information	Comment	Organism
metabolism	citramalate synthase acts in the alternative isoleucine synthesis pathway present in cyanobacteria, such as Cyanothece and Synechococcus. The pathway has been detected first in mostly anaerobic bacteria or archaea	Crocosphaera subtropica ATCC 51142
physiological function	synthesis of isoleucine from citramalate via condensation of acetyl-CoA and pyruvate catalysed by citramalate synthase, CimA	Crocosphaera subtropica ATCC 51142

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Release 2023.1 (January 2023)