Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | G5EDT9 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
sog-1 | - |
Caenorhabditis elegans |
UBR E3 ubiquitin ligase homolog | - |
Caenorhabditis elegans |
Ubr-5 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | loss of Ubr-5 function suppresses defects caused by reduced signaling via Notch-type receptors GLP-1 or LIN-12. Ubr-5 mutations do not suppress embryonic or larval lethality associated with mutations in downstream transcription factor, LAG-1. In the gonad, Ubr-5 acts in the receiving cells (germ cells) to limit GLP-1 signaling activity. Ubr-5 acts redundantly with the F-box component of SCFSEL-10 E3 ubiquitin-ligase SEL-10 to limit Notch signaling in certain tissues | Caenorhabditis elegans |