Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5T447 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[ubiquitin ligase HECTD3]-S-ubiquitin-L-cysteine + [Tara]-L-lysine | Tara, Trio-associated repeat on actin, is an interacting partner of guanine nucleotide exchange factors Trio and TRF1. Ubiquitin-protein ligase HECTD3 directly binds Tara in vitro and forms a complex with Tara in vivo. Overexpression of HECTD3 enhances the ubiquitination of Tara in vivo and promotes the turnover of Tara, whereas depletion of HECTD3 by small interfering RNA decreases Tara degradation | Homo sapiens | [ubiquitin ligase HECTD3]-L-cysteine + [Tara]-N6-ubiquitinyl-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HECTD3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | depletion of ubiquitin-protein ligase HECTD3 leads to multipolar spindle formation | Homo sapiens |