Cloned (Comment) | Organism |
---|---|
wild-type and mutant enzymes are expressed in Sf9 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K1699A | specific activity is 10% of wild-type value | Homo sapiens |
K1699Q | specific activity is 7.5% of wild-type value | Homo sapiens |
S2151A | inactive enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
acetyl-CoA | 25°C, pH 7.0, mutant enzyme K1699Q | Homo sapiens | |
0.001 | - |
malonyl-CoA | 25°C, pH 7.0, mutant enzyme K1699Q | Homo sapiens | |
0.003 | - |
malonyl-CoA | 25°C, pH 7.0, mutant enzyme K1699A | Homo sapiens | |
0.005 | - |
NADPH | 25°C, pH 7.0, wild-type enzyme | Homo sapiens | |
0.006 | - |
malonyl-CoA | 25°C, pH 7.0, wild-type enzyme | Homo sapiens | |
0.007 | - |
acetyl-CoA | 25°C, pH 7.0, wild-type enzyme | Homo sapiens | |
0.007 | - |
acetyl-CoA | 25°C, pH 7.0, mutant enzyme K1699A | Homo sapiens | |
0.37 | - |
NADPH | 25°C, pH 7.0, mutant enzyme K1699A | Homo sapiens | |
0.4 | - |
NADPH | 25°C, pH 7.0, mutant enzyme K1699Q | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Homo sapiens | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
acetyl-CoA | mutant enzyme K1699Q | Homo sapiens | |
0.3 | - |
malonyl-CoA | mutant enzyme K1699Q | Homo sapiens | |
0.32 | - |
acetyl-CoA | mutant enzyme K1699A | Homo sapiens | |
0.32 | - |
malonyl-CoA | mutant enzyme K1699A | Homo sapiens | |
2.7 | - |
acetyl-CoA | wild-type enzyme | Homo sapiens | |
2.7 | - |
malonyl-CoA | wild-type enzyme | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |