Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | bombesin induces p300 expression 2fold, as part of the Src and PKCdelta pathways, a neutral endopeptidase, which degrades bombesin, or bombesin receptor antagonists, or p300 siRNA block bombesin-induced p300 HAT activity, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
androgen receptor + acetyl-CoA | Homo sapiens | receptor signaling in prostate cancer cells is augmented by the androgen receptor coactivator p300, which transactivates and acetylates the androgen receptor in the presence of 100 nM dihydrotestosterone, involvement of p300 in neuropeptide activation of androgen receptor signaling, overview | acetylated androgen receptor + CoA | - |
? | |
additional information | Homo sapiens | androgen Src kinase and PKCd kinase are involved in the regulation of p300 HAT activity via bombesin, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C4-2 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activation of p300 HAT activity and acetylation of the AR by bombesin in PC cells | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androgen receptor + acetyl-CoA | receptor signaling in prostate cancer cells is augmented by the androgen receptor coactivator p300, which transactivates and acetylates the androgen receptor in the presence of 100 nM dihydrotestosterone, involvement of p300 in neuropeptide activation of androgen receptor signaling, overview | Homo sapiens | acetylated androgen receptor + CoA | - |
? | |
androgen receptor + acetyl-CoA | the KLKK motif of androgen receptor protein is both necessary and sufficient for acetylation by p300 in the presence of 100 nM dihydrotestosterone | Homo sapiens | acetylated androgen receptor + CoA | - |
? | |
additional information | androgen Src kinase and PKCd kinase are involved in the regulation of p300 HAT activity via bombesin, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
p300 | - |
Homo sapiens |