Crystallization (Comment) | Organism |
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structures of free LpxA and its complexes with its product UDP-3-N-(R-3-hydroxylauroyl)-GlcNAc3N and with its substrate R-3-hydroxylauroyl-methylphosphopantetheine. The selectivity of LiLpxA for UDPGlcNAc3N may be explained by the orientation of the backbone carbonyl group of Q68, which differs by about 82° from the corresponding Q73 carbonyl group in Escherichia coli LpxA. The R-3-hydroxylauroyl selectivity of LpxA is explained by the position of the K171 side chain, which limits the length of the acyl-chain-binding groove | Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV |
Organism | UniProt | Comment | Textmining |
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Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV | Q8EZA6 | - |
- |
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV 56601 | Q8EZA6 | - |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3R)-3-hydroxylauroyl-[acyl-carrier protein] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose | - |
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV | acyl-carrier protein + UDP-2-acetamido-2,3-dideoxy-3-[[(3R)-3-hydroxylauroyl]amino]-alpha-D-glucopyranose | - |
? | |
(3R)-3-hydroxylauroyl-[acyl-carrier protein] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose | - |
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV 56601 | acyl-carrier protein + UDP-2-acetamido-2,3-dideoxy-3-[[(3R)-3-hydroxylauroyl]amino]-alpha-D-glucopyranose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LpxA | - |
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV |