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Literature summary for 2.3.1.291 extracted from

  • Sassa, T.; Hirayama, T.; Kihara, A.
    Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region (2016), J. Biol. Chem., 291, 7477-7487 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.291

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell Mus musculus
expression in HEK-293T cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N5B7
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-
Homo sapiens Q8N5B7 isoform CerS5
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Mus musculus Q9D6K9
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens
phosphoprotein dephosphorylation of endogenous ceramide synthases in the mouse brain leads to modestly reduced activity toward the Cers5/6 substrate C16:0-CoA Mus musculus
phosphoprotein phosphorylation modestly increases the catalytic activities of Cers5 Homo sapiens
phosphoprotein isoform Cers5 is phosphorylated at the cytoplasmic C-terminal region. Treatment with lambda protein phosphatase reduces the activity by 27% Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information expression of CERS5 increases the level of C16:0-ceramide and decreases levels of C18:0-ceramide, C22:0-ceramide, and C24-ceramides Homo sapiens ?
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palmitoyl-CoA + sphingosine
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 Homo sapiens CoA + N-palmitoylsphingosine
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 ?