Application | Comment | Organism |
---|---|---|
medicine | CerS1 and CerS5 mRNA expression is reduced in muscle biopsies from patients in advanced stage of chronic heart failure suffering from muscle wasting and frailty | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N5B7 | isoform CerS5 | - |
Mus musculus | Q9D6K9 | isoform CerS5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | an age-dependent decline of both isoforms CerS1 and CerS5 mRNA expression is observed in skeletal muscle biopsies | Homo sapiens | - |
skeletal muscle | the expression of CerS1 and CerS5 mRNA, encoding the ceramide synthases with substrate preference for C16:0 and C18:0 acyl chains, respectively, is downregulated in skeletal muscle of aged mice | Mus musculus | - |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression of CerS1 and CerS5 mRNA, encoding the ceramide synthases with substrate preference for C16:0 and C18:0 acyl chains, respectively, is downregulated in skeletal muscle of aged mice | down |
General Information | Comment | Organism |
---|---|---|
physiological function | skeletal muscle from mice deficient of either CerS1 or CerS5 shows reduced caliber sizes of both slow (type 1) and fast (type 2) muscle fibers, fiber grouping, and fiber switch to type 1 fibers. CerS1- and CerS5-deficient mice exhibit reduced twitch and tetanus forces of musculus extensor digitorum longus | Mus musculus |