Literature summary for 2.3.1.285 extracted from

Li, Y.; Li, S.; Thodey, K.; Trenchard, I.; Cravens, A.; Smolke, C.
Complete biosynthesis of noscapine and halogenated alkaloids in yeast (2018), Proc. Natl. Acad. Sci. USA, 115, E3922-E3931 .

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Application

Application	Comment	Organism
synthesis	de novo production of noscapine in Saccharomyces cerevisiae, through the reconstruction of a biosynthetic pathway comprising over 30 enzymes from plants, bacteria, mammals, and yeast itself. Optimization of conditions leads to an over 18,000fold improvement from initial noscapine titers to about2.2 mg/l. By feeding modified tyrosine derivatives to the optimized noscapine-producing strain, microbial production of halogenated benzylisoquinoline alkaloids is possible	Papaver somniferum

Organism

Organism	UniProt	Comment	Textmining
Papaver somniferum	I3PLR4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + (13S,14R)-1,13-dihydroxy-N-methylcanadine	-	Papaver somniferum	(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA	-	?

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Release 2023.1 (January 2023)