Cloned (Comment) | Organism |
---|---|
gene fabH, overexpression of His-tagged enzyme in Mycobacterium bovis strain BCG | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ampicillin | inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo | Mycobacterium tuberculosis | |
Ethionamide | inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo | Mycobacterium tuberculosis | |
isoniazid | inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo | Mycobacterium tuberculosis | |
isoxyl | inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo | Mycobacterium tuberculosis | |
additional information | the mitochondrial enzyme is not affected by cerulenin | Mycobacterium tuberculosis | |
rifampicin | inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo | Mycobacterium tuberculosis | |
thiolactomycin | inhibition of the purified enzyme in vitro, and of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo | Mycobacterium tuberculosis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
x * 43000, recombinant His-tagged enzyme, SDS-PAGE | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | the condensation reaction is the first step in elongation in fatty acid synthesis by fatty acid synthase complex | acetoacyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged enzyme from Mycobacterium bovis strain BCG | Mycobacterium tuberculosis |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | active site structure a catayltic triad of Cys-His-Asn residues | Mycobacterium tuberculosis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificity of the purified His-tagged enzyme | Mycobacterium tuberculosis |
0.00013 | - |
purified His-tagged enzyme, substrate lauroyl-CoA | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + malonyl-[acyl-carrier protein] | the condensation reaction is the first step in elongation in fatty acid synthesis by fatty acid synthase complex | Mycobacterium tuberculosis | acetoacyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
arachidoyl-CoA + malonyl-[acyl-carrier protein] | low activity | Mycobacterium tuberculosis | 3-oxo-docosanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
decanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxo-lauroyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
lauroyl-CoA + malonyl-[acyl-carrier protein] | lauroyl-CoA is the preferred primer | Mycobacterium tuberculosis | 3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
additional information | substrate specificity, no activity with isovaleryl-CoA, butyryl-CoA, and acetyl-CoA, the enzyme prefers long chain acyl-CoAs as primers rather than acyl-ACPs | Mycobacterium tuberculosis | ? | - |
? | |
myristoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
octanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
palmitoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
stearoyl-CoA + malonyl-[acyl-carrier protein] | low activity | Mycobacterium tuberculosis | 3-oxo-arachidoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 43000, recombinant His-tagged enzyme, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl (acyl carrier protein) synthase III | - |
Mycobacterium tuberculosis |
beta-ketoacyl-ACP III | - |
Mycobacterium tuberculosis |
FabH | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mycobacterium tuberculosis |