Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
CO | a cobalt-containing Co/Fe-S component of multienzyme complex serves as a methyl carrier in the pathway of methane synthesis from acetate | Moorella thermoacetica | |
Fe | corrinoid/iron-sulfur protein required | Moorella thermoacetica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Moorella thermoacetica | key enzyme in the autotrophic acetyl-CoA pathway, i.e. Wood pathway, enzyme catalyses the final steps in this pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Moorella thermoacetica | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] | the FeS cluster is present to relay electrons from enzyme to CO | Moorella thermoacetica | |
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] | the transfer of methyl group to enzyme occurs by SN2-type nucleophilic displacement, not a radical, reaction | Moorella thermoacetica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CH3-(corrinoid/iron-sulfur protein) + CO + HS-CoA | under anaerobic conditions | Moorella thermoacetica | CH3-CO-S-CoA + corrinoid/iron-sulfur protein | - |
? | |
CH3-tetrahydrofolate + CO + HS-CoA | - |
Moorella thermoacetica | CH3-CO-S-CoA + tetrahydrofolate | - |
? | |
CO + methyl-X + HS-CoA | - |
Moorella thermoacetica | CH3-CO-S-CoA + HX | - |
? | |
additional information | key enzyme in the autotrophic acetyl-CoA pathway, i.e. Wood pathway, enzyme catalyses the final steps in this pathway | Moorella thermoacetica | ? | - |
? |