Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SKF 98625 | a reversible antagonist of CoA-IT, in vitro and in vivo inhibition, induces eosinophil apoptosis in vitro | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
individuals with and without asthma | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eosinophil | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CoA-independent transacylase | - |
Homo sapiens |
CoA-IT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.005 | 0.01 | pH 7.4, 37°C, in cell-free assays | Homo sapiens | SKF 98625 | |
0.015 | 0.025 | pH 7.4, 37°C, in whole cell assays | Homo sapiens | SKF 98625 |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme participates in the high affinity-low capacity pathway. Cells use this pathway to rapidly incorporate and remodel arachinonic acid through various glycerophospholipids. The predominant enzymes in this pathway include long chain fatty-acid ligase, lysophospholipid: acyl-CoA acyltransferase, and acyl-CoA independent transacylase, overview | Homo sapiens |
physiological function | arachidonic acid-phospholipid remodeling orchestrated by CoA-IT and gIVaPLA2 may function to regulate eosinophil apoptosis, overview. Regulation of arachidonic acid and phospholipid remodeling enzymes provides a mechanism for regulating not only eicosanoid production, but also the increased life-span of eosinophils in allergic asthma, overview | Homo sapiens |