Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5SQI0 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ATAT1 | - |
Homo sapiens |
Mec-17 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of MEC-17 in A-549 cells enhances the cell spreading area, suppresses pseudopods formation in a three-dimensional culture system, and inhibits cancer cell migratory and invasive ability and tumour metastasis by orthotopic lung cancer animal model. Morphological change and migration inhibition of cancer cells are accompanied by epithelial-mesenchymal transition repression, Golgi reorientation, and polarity disruption caused by alteration of Cdc42 activity via a decrease in Rho-GAP, ARHGAP21. A reduction in endogenous MEC-17 accelerates the pseudopods formation and epithelial-mesenchymal transition, and facilitates cell migration and invasion | Homo sapiens |