Cloned (Comment) | Organism |
---|---|
genes alphaTAT/MEC-17, phylogenetic analysis | Homo sapiens |
genes alphaTAT/MEC-17, phylogenetic analysis | Caenorhabditis elegans |
genes alphaTAT/MEC-17, phylogenetic analysis | Tetrahymena sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [alpha-tubulin]-L-lysine | Homo sapiens | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
acetyl-CoA + [alpha-tubulin]-L-lysine | Caenorhabditis elegans | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
acetyl-CoA + [alpha-tubulin]-L-lysine | Tetrahymena sp. | - |
CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
additional information | Homo sapiens | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | ? | - |
? | |
additional information | Caenorhabditis elegans | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | ? | - |
? | |
additional information | Tetrahymena sp. | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Homo sapiens | - |
- |
- |
Tetrahymena sp. | - |
gene MEC17 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | most Caenorhabditis elegans-ciliated sensory neurons lack detectable acetylated tubulin | Caenorhabditis elegans | - |
neuron | MEC-12 is present in touch receptor neurons and other (ciliated) neurons. mec-17 expression is limited to touch receptor neurons, its paralogue atat-2 is also expressed in some ciliated neurons | Caenorhabditis elegans | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [alpha-tubulin]-L-lysine | - |
Homo sapiens | CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
acetyl-CoA + [alpha-tubulin]-L-lysine | - |
Caenorhabditis elegans | CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
acetyl-CoA + [alpha-tubulin]-L-lysine | - |
Tetrahymena sp. | CoA + [alpha-tubulin]-N6-acetyl-L-lysine | - |
? | |
additional information | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | Homo sapiens | ? | - |
? | |
additional information | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | Caenorhabditis elegans | ? | - |
? | |
additional information | alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones | Tetrahymena sp. | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alphaTAT | - |
Homo sapiens |
alphaTAT | - |
Caenorhabditis elegans |
alphaTAT | - |
Tetrahymena sp. |
Mec-17 | - |
Homo sapiens |
Mec-17 | - |
Caenorhabditis elegans |
Mec-17 | - |
Tetrahymena sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens | |
acetyl-CoA | - |
Caenorhabditis elegans | |
acetyl-CoA | - |
Tetrahymena sp. |
General Information | Comment | Organism |
---|---|---|
evolution | distribution of alphaTAT/MEC-17 across all eukaryotic clades reveals that it was present in the last eukaryotic common ancestor, which was ciliated | Homo sapiens |
evolution | distribution of alphaTAT/MEC-17 across all eukaryotic clades reveals that it was present in the last eukaryotic common ancestor, which was ciliated | Caenorhabditis elegans |
evolution | distribution of alphaTAT/MEC-17 across all eukaryotic clades reveals that it was present in the last eukaryotic common ancestor, which was ciliated | Tetrahymena sp. |
malfunction | a delay in cilium formation for cultured human cells depleted of alphaTAT/MEC-17 | Homo sapiens |
malfunction | disrupting MEC17 in Tetrahymena abolishes tubulin acetylation, but no overt defect in cilium formation or motility occurs | Tetrahymena sp. |
malfunction | loss of Caenorhabditis elegans alphaTAT activity in the mec-17, atat-2 double mutant affects touch receptor neuron mechanosensation to a greater extent than having a nonacetylatable MEC-12 (K40R) form of tubulin in the organism | Caenorhabditis elegans |
physiological function | MEC-17 and ATAT-2 are required for body touch sensation, which depends on the nonciliated, acetylated tubulin-containing touch receptor neurons. ATAT-2 is needed for acetylating tubulin in dendritic processes and cilia in those neurons. Additional role(s) for the acetyltransferase independent of tubulin acetylation | Caenorhabditis elegans |