Protein Variants | Comment | Organism |
---|---|---|
A10S | the mutation alters the structure and function of the enzyme, thereby causing mitochondrial dysfunction, and interacts with 12S rRNA 1555A->G mutation to cause deafness. The mutation causes marked decreases in 2-thiouridine modification of U34 of tRNALys (48% decrease), tRNAGlu (38% decrease) and tRNAGln (50% decrease). However, the mutation mildly increases the aminoacylated efficiency of tRNA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
methylaminomethyl-2-thiouridylate-methyltransferase | - |
Homo sapiens |
TRMU | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
45.9 | - |
melting temperature of the mutant enzyme A10S | Homo sapiens |
49.1 | - |
melting temperature of the wild type enzyme | Homo sapiens |