Cloned (Comment) | Organism |
---|---|
DNMT1 and DNMT3a, expression analysis of the isozymes in salivary gland neoplasmata | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | DNMT1 | Homo sapiens | 5737 | - |
nucleus | DNMT1 and DNMT3a | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes DNMT1 and DNMT3a | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | DNMTs are overexpressed in tumorigenic cell lines and in a few types of human neoplasms | Homo sapiens | - |
salivary gland | immunohistochemical analysis | Homo sapiens | - |
salivary gland cancer cell | pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma and polymorphous low-grade adenocarcinoma of lower lip, buccal mucosa, mandible, tongue, floor, or palate. Positive nuclear and cytoplasmic labeling for DNMT1 occurs in all samples, positive nuclear labeling for DNMT3a occurs only in few neoplasms: 1 pleomorphic adenoma, 2 adenoid cystic carcinoma and 1 mucoepidermoid cases, immunohistochemical | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Dnmt1 | - |
Homo sapiens |
Dnmt3a | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | while DNMT3a is mostly involved in de novo methylation, DNMT1 acts as a maintenance methyltransferase | Homo sapiens |