Protein Variants | Comment | Organism |
---|---|---|
additional information | even modest increases or decreases in levels of m5C cause severe abnormalities or death in mutant mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Mus musculus | both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | Homo sapiens | both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
additional information | Homo sapiens | upon activation of ER-target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview | ? | - |
? | |
additional information | Mus musculus | upon activation of ER? target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroleukemia cell | - |
Mus musculus | - |
HeLa cell | - |
Homo sapiens | - |
RKO cell | a human colorectal carcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | - |
Mus musculus | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | - |
Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes | Mus musculus | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes | Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
additional information | upon activation of ER-target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview | Homo sapiens | ? | - |
? | |
additional information | upon activation of ER? target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dnmt3a | - |
Mus musculus |
Dnmt3a | - |
Homo sapiens |
DNMT3B | - |
Mus musculus |
DNMT3B | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus | |
S-adenosyl-L-methionine | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | both DNMT3A and DNMT3B are involved in de novo DNA methylation | Mus musculus |
metabolism | both DNMT3A and DNMT3B are involved in de novo DNA methylation | Homo sapiens |