Cloned (Comment) | Organism |
---|---|
enzyme is encoded by the nonessential TRM2 gene | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
C521A | mutant without methyltransferase activity, putative nucleophilic Cys-521 may be involved in Cys-U54 bond formation | Saccharomyces cerevisiae |
G428D | mutant without methyltransferase activity, G-428 is located at the presumed S-adenosyl-L-methionine binding site | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + uridine54 in tRNA | Saccharomyces cerevisiae | role per se in tRNA maturation, stabilization of tRNA, early event in tRNA maturation: intron-containing pre-tRNAs contain m5U | S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
several strains | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | absence of TRM2 gene encoding enzyme in strains with mutant forms of tRNASerCGA decreases the stability of tRNASerCGA and induces lethality | Saccharomyces cerevisiae | additional information | - |
? | |
S-adenosyl-L-methionine + uridine54 in tRNA | methylation of U54 | Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA | nearly all tRNAs contain m5U54, initiators excluded | ? | |
S-adenosyl-L-methionine + uridine54 in tRNA | role per se in tRNA maturation, stabilization of tRNA, early event in tRNA maturation: intron-containing pre-tRNAs contain m5U | Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae |