Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BND5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 dithiothreitol + O2 | - |
Mus musculus | dithiothreitol disulfide + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
QSOx1 | - |
Mus musculus |
quiescin sulfhydryl oxidase 1 | - |
Mus musculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
56.2 | - |
midpoint of thermal denaturation, mutant enzyme H72A/P119S | Mus musculus |
62.4 | - |
midpoint of thermal denaturation, wild-type enzyme | Mus musculus |
63.2 | - |
midpoint of thermal denaturation, mutant enzyme P119S | Mus musculus |
63.2 | - |
midpoint of thermal denaturation, mutant enzyme P119T | Mus musculus |
67.9 | - |
midpoint of thermal denaturation, mutant enzyme H72A | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations at a cis-proline in QSOX1 that is conserved across the thioredoxin superfamily result in QSOX1 variants that showed a striking detrimental effect when added exogenously to fibroblasts. They severely disrupt the extracellular matrix and cell adhesion, even in the presence of naturally secreted, wild-type enzyme (QSOX1) | Mus musculus |
physiological function | among other potential functions, QSOX1 supports extracellular matrix assembly in fibroblast cultures | Mus musculus |