Literature summary for 1.5.1.3 extracted from

Corral, M.; Haywood, J.; Stehl, L.; Stubbs, K.; Murcha, M.; Mylne, J.
Targeting plant dihydrofolate reductase with antifolates and mechanisms for genetic resistance (2018), Plant J., 95, 727-742 .

Search for more literature for 1.5.1.3

Protein Variants

Protein Variants	Comment	Organism
A71V	mutation confers resistance to antimalarial DHFR inhibitor drug cycloguanil, mutation is in the DHFR domain, close to the binding sites for DHF	Arabidopsis thaliana
G137D	mutation confers resistance to antimalarial DHFR inhibitor drugs pyrimethamine and cycloguanil, mutation is in the DHFR domain, close to the binding sites for DHF	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Arabidopsis thaliana	5737	-
mitochondrion	-	Arabidopsis thaliana	5739	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q05762	bifunctional dihydrofolate reductase-thymidylate synthase 1, cf. EC 2.1.1.45	-
Arabidopsis thaliana	Q05763	bifunctional dihydrofolate reductase-thymidylate synthase 2, cf. EC 2.1.1.45	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	DHFR-TS1 is alternatively spliced in mature leaves	Arabidopsis thaliana	-
seed	-	Arabidopsis thaliana	-

Synonyms

Synonyms	Comment	Organism
At2g16370	-	Arabidopsis thaliana
At4g34570	-	Arabidopsis thaliana
DHFR-TS1	-	Arabidopsis thaliana
DHFR-TS2	-	Arabidopsis thaliana
THY-1	-	Arabidopsis thaliana
THY-2	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)