Application | Comment | Organism |
---|---|---|
drug development | expression of bifunctional dihydrofolate reductase-thymidylate synthase in plasmodium falciparum to assess interaction with antifolates | Plasmodium vivax |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of mutant AMRU1, i.e. 57L/58R/61M/1117T, in Plasmodium falciparum provides significant protection against pyrimethamine, cycloguanil, and clociguanil. It confers greater resistance to cycloguanil, clociguanil, and WR99210 than the homologous Plasmodium falciparum mutant | Plasmodium vivax |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clociguanil | - |
Plasmodium vivax | |
cycloguanil | - |
Plasmodium vivax | |
pyrimethamine | - |
Plasmodium vivax | |
WR99210 | - |
Plasmodium vivax |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium vivax | Q00NX3 | fragment; bifunctional dihydrofolate reductase-thymidylate synthase | - |