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Literature summary for 1.4.3.3 extracted from

  • Jagannath, V.; Brotzakis, Z.; Parrinello, M.; Walitza, S.; Gruenblatt, E.
    Controversial effects of D-amino acid oxidase activator (DAOA)/G72 on D-amino acid oxidase (DAO) activity in human neuronal, astrocyte and kidney cell lines The N-methyl D-aspartate (NMDA) receptor hypofunction point of view (2017), Front. Mol. Neurosci., 10, 342 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in SH-SY5Y, 1321-N1 and HEK-293 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
1321-N1 cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function presence of DAO activator protein DAOA/G72 increases DAO activity only in HEK-293 cells, but has no effect on DAO activity in SH-SY5Y and 1321-N1 cells. The DAO holoenzyme becomes more flexible and misfolded in the presence of DAOA, whereas DAOA has no effect on DAO apoprotein. DAOA displays no effect on NMDA receptor activity in NR1/NR2A HEK-293 cells Homo sapiens