Cloned (Comment) | Organism |
---|---|
expression in CHO cells | Homo sapiens |
expression in CHO cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4H-thieno [3,2-b]pyrrole-5-carboxylic acid | i.e. compound 8, a moderately potent inhibitor of human DAAO in vitro | Homo sapiens | |
4H-thieno [3,2-b]pyrrole-5-carboxylic acid | i.e. compound 8, a moderately potent inhibitor of rat DAAO in vitro, inhibits DAAO activity in kideny by 96% and in brain by 80% resulting in a significant elevation in both plasma and cerebrospinal fluid D-serine concentration. Compound 8 fails to significantly influence amphetamine-induced psychomotor activity, nucleus accumbens dopamine release, or a dizocilpine maleate-induced deficit in novel object recognition in rats | Rattus norvegicus | |
5-methyl-1H-pyrazole-3-carboxylic acid | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | Homo sapiens | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | Rattus norvegicus | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Homo sapiens | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Rattus norvegicus | high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cerebellum and cortex | Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | - |
Homo sapiens | pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | - |
Rattus norvegicus | pyruvate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | - |
Rattus norvegicus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition | Rattus norvegicus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAAO | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
assay at | Homo sapiens |
8.2 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000114 | - |
- |
Rattus norvegicus | 4H-thieno [3,2-b]pyrrole-5-carboxylic acid | |
0.000145 | - |
- |
Homo sapiens | 4H-thieno [3,2-b]pyrrole-5-carboxylic acid |