Literature summary for 1.3.98.5 extracted from

Dailey, H.; Gerdes, S.; Dailey, T.; Burch, J.; Phillips, J.
Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin (2015), Proc. Natl. Acad. Sci. USA, 112, 2210-2215 .

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Organism

Organism	UniProt	Comment	Textmining
Firmicutes	-	-	-

General Information

General Information	Comment	Organism
physiological function	Actinobacteria and Firmicutes (high-GC and low-GC Gram-positive bacteria) are unable to synthesize protoporphyrin. Instead, they oxidize coproporphyrinogen to coproporphyrin, insert ferrous iron to make Fe-coproporphyrin (coproheme), and then decarboxylate coproheme to generate protoheme. This pathway is specified by three genes named hemY, hemH, and hemQ and is the most ancient heme synthesis pathway in the Eubacteria	Firmicutes

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Release 2023.1 (January 2023)