Application | Comment | Organism |
---|---|---|
medicine | species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics | Mus musculus |
medicine | species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics | Escherichia coli |
medicine | species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics | Rattus norvegicus |
medicine | species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics | Pseudomonas aeruginosa |
medicine | species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics | Pseudomonas putida |
medicine | species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors, and thus siccanin is a potential lead compound for new chemotherapeutics | Corynebacterium glutamicum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | residual activity: 97%. Structure of siccanin is similar to ubiquinone-1. Siccanin, is effective against enzymes from Pseudomonas aeruginosa, Pseudomonas putida, rat and mouse mitochondria but ineffective or less effective against Escherichia coli, Corynebacterium glutamicum, and porcine mitochondria enzyme. Action mode is mixed-type for quinone-dependent activity and non-competitive for succinate-dependent activity, indicating the proximity of the inhibitor-binding site to the quinone-binding site | Corynebacterium glutamicum | |
additional information | residual activity: above 77%. Structure of siccanin is similar to ubiquinone-1. Siccanin, is effective against enzymes from Pseudomonas aeruginosa, Pseudomonas putida, rat and mouse mitochondria but ineffective or less effective against Escherichia coli, Corynebacterium glutamicum, and porcine mitochondria enzyme. Action mode is mixed-type for quinone-dependent activity and non-competitive for succinate-dependent activity, indicating the proximity of the inhibitor-binding site to the quinone-binding site | Escherichia coli | |
siccanin | - |
Escherichia coli | |
siccanin | residual activity: 7%. Structure of siccanin is similar to ubiquinone-1. Siccanin, is effective against enzymes from Pseudomonas aeruginosa, Pseudomonas putida, rat and mouse mitochondria but ineffective or less effective against Escherichia coli, Corynebacterium glutamicum, and porcine mitochondria enzyme. Action mode is mixed-type for quinone-dependent activity and non-competitive for succinate-dependent activity, indicating the proximity of the inhibitor-binding site to the quinone-binding site | Mus musculus | |
siccanin | residual activity: 13%. Structure of siccanin is similar to ubiquinone-1. Siccanin, is effective against enzymes from Pseudomonas aeruginosa, Pseudomonas putida, rat and mouse mitochondria but ineffective or less effective against Escherichia coli, Corynebacterium glutamicum, and porcine mitochondria enzyme. Action mode is mixed-type for quinone-dependent activity and non-competitive for succinate-dependent activity, indicating the proximity of the inhibitor-binding site to the quinone-binding site | Pseudomonas aeruginosa | |
siccanin | residual activity: above 1%. Structure of siccanin is similar to ubiquinone-1. Siccanin, is effective against enzymes from Pseudomonas aeruginosa, Pseudomonas putida, rat and mouse mitochondria but ineffective or less effective against Escherichia coli, Corynebacterium glutamicum, and porcine mitochondria enzyme. Action mode is mixed-type for quinone-dependent activity and non-competitive for succinate-dependent activity, indicating the proximity of the inhibitor-binding site to the quinone-binding site | Pseudomonas putida | |
siccanin | residual activity: 19%. Structure of siccanin is similar to ubiquinone-1. Siccanin, is effective against enzymes from Pseudomonas aeruginosa, Pseudomonas putida, rat and mouse mitochondria but ineffective or less effective against Escherichia coli, Corynebacterium glutamicum, and porcine mitochondria enzyme. Action mode is mixed-type for quinone-dependent activity and non-competitive for succinate-dependent activity, indicating the proximity of the inhibitor-binding site to the quinone-binding site | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | membrane-bound enzyme is used | Escherichia coli | 16020 | - |
membrane | membrane-bound enzyme is used | Pseudomonas putida | 16020 | - |
membrane | membrane-bound SDH is used | Pseudomonas aeruginosa | 16020 | - |
membrane | membrane-bound SDH is used | Corynebacterium glutamicum | 16020 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium glutamicum | - |
- |
- |
Escherichia coli | - |
- |
- |
Mus musculus | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas putida | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquinone-1 + L-malate | - |
Mus musculus | ? | - |
? | |
ubiquinone-1 + L-malate | - |
Escherichia coli | ? | - |
? | |
ubiquinone-1 + L-malate | - |
Rattus norvegicus | ? | - |
? | |
ubiquinone-1 + L-malate | - |
Pseudomonas aeruginosa | ? | - |
? | |
ubiquinone-1 + L-malate | - |
Pseudomonas putida | ? | - |
? | |
ubiquinone-1 + L-malate | - |
Corynebacterium glutamicum | ? | - |
? | |
ubiquinone-1 + succinate | - |
Mus musculus | ubiquinol + fumarate | - |
? | |
ubiquinone-1 + succinate | - |
Rattus norvegicus | ubiquinol + fumarate | - |
? | |
ubiquinone-1 + succinate | - |
Escherichia coli | ubiquinol-1 + fumarate | - |
? | |
ubiquinone-1 + succinate | - |
Pseudomonas aeruginosa | ubiquinol-1 + fumarate | - |
? | |
ubiquinone-1 + succinate | - |
Pseudomonas putida | ubiquinol-1 + fumarate | - |
? | |
ubiquinone-1 + succinate | - |
Corynebacterium glutamicum | ubiquinol-1 + fumarate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SDH | - |
Mus musculus |
SDH | - |
Escherichia coli |
SDH | - |
Rattus norvegicus |
SDH | - |
Pseudomonas aeruginosa |
SDH | - |
Pseudomonas putida |
SDH | - |
Corynebacterium glutamicum |
succinate dehydrogenase | - |
Mus musculus |
succinate dehydrogenase | - |
Escherichia coli |
succinate dehydrogenase | - |
Rattus norvegicus |
succinate dehydrogenase | - |
Pseudomonas aeruginosa |
succinate dehydrogenase | - |
Pseudomonas putida |
succinate dehydrogenase | - |
Corynebacterium glutamicum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mus musculus |
25 | - |
assay at | Escherichia coli |
25 | - |
assay at | Rattus norvegicus |
25 | - |
assay at | Pseudomonas aeruginosa |
25 | - |
assay at | Pseudomonas putida |
25 | - |
assay at | Corynebacterium glutamicum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Escherichia coli |
7.4 | - |
assay at | Rattus norvegicus |
7.4 | - |
assay at | Pseudomonas aeruginosa |
7.4 | - |
assay at | Pseudomonas putida |
7.4 | - |
assay at | Corynebacterium glutamicum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0009 | - |
pH 7.4, 25°C | Pseudomonas aeruginosa | siccanin | |
0.009 | - |
pH 7.4, 25°C | Rattus norvegicus | siccanin | |
0.21 | - |
- |
Escherichia coli | siccanin |