Cloned (Comment) | Organism |
---|---|
gene SDHB, chromoslomal location at 1p36.13, DNA and amino acid sequence determination and analysis of wild-type and mutant enzymes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | determination of distinct heterozygous SDHB missense DNA mutations, the mutational mechanism targeting SDHB is operational in T-cell acute leukemia, overview | Homo sapiens |
R46X | naturally ocurring mutations, the recurrent stop-codon mutation in succinate dehydrogenase subunit B gene might play a role in cellular pre-adaptation to hypoxia in normal peripheral blood and childhood T-cell acute leukemia, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | germline mutations in the SDHB, SDHC or SDHD genes cause hereditary paraganglioma tumors which show constitutive activation of homeostatic mechanisms induced by oxygen deprivation/hypoxia, overview | ? | - |
? | |
succinate + ubiquinone | Homo sapiens | - |
fumarate + ubiquinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
T-cell | CD4+ | Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
TALL-104 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | germline mutations in the SDHB, SDHC or SDHD genes cause hereditary paraganglioma tumors which show constitutive activation of homeostatic mechanisms induced by oxygen deprivation/hypoxia, overview | Homo sapiens | ? | - |
? | |
succinate + ubiquinone | - |
Homo sapiens | fumarate + ubiquinol | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ubiquinone | - |
Homo sapiens |