Application | Comment | Organism |
---|---|---|
medicine | first patient with porphyria where both CPO and delta-aminolaevulinic acid dehydratase are deficient at the molecular level | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
mature form of wild-type CPOX cloned into pET-22, wild-type and mutant protein expressed in Escherichia coli BL21(DE3)plysS | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G279R | novel nucleotide transition found, is unstable, and produces ca. 2-5% of activity compared with the wild-type CPO | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P36551 | male patient with a typical attack of hepatic porphyria | - |
Purification (Comment) | Organism |
---|---|
by Ni2+ affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
coproporphyrinogen-III + O2 + 2 H+ | - |
Homo sapiens | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
coproporphyrinogen oxidase | - |
Homo sapiens |
CPO | - |
Homo sapiens |
CPOX | - |
Homo sapiens |