Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Leishmania major | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Leishmania major | - |
promastigote | - |
Leishmania major | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+ | - |
Leishmania major | (2E)-2-decaenoyl-CoA + NADP+ | - |
? |
Organism | Comment | Expression |
---|---|---|
Leishmania major | expression of DECR is highly upregulated in amastigote stages | up |
General Information | Comment | Organism |
---|---|---|
physiological function | DECR is the major reductase involved in polyunsaturated fatty acid beta-oxidation. DECR is related to bacterial reductases. A DECR null mutant is unable to catabolize unsaturated fatty acids and accumulates the intermediate 2,4-decadienoyl-CoA. The mutant is unable to survive in macrophages and is avirulent in BALB/c mice | Leishmania major |