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Literature summary for 1.3.1.122 extracted from

  • Nguyen, T.D.; OConnor, S.E.
    The Progesterone 5beta-reductase/iridoid synthase family A catalytic reservoir for specialized metabolism across land plants (2020), ACS Chem. Biol., 15, 1780-1787 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.122

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0046
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Selaginella moellendorffii
0.007
-
 (6E)-8-oxogeranial pH 7, 22°C Coccomyxa subellipsoidea
0.007
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Arabidopsis thaliana
0.0085
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Catharanthus roseus
0.0177
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Digitalis purpurea
0.031
-
 (6E)-8-oxogeranial pH 7, 22°C Coccomyxa subellipsoidea
0.042
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Arabidopsis thaliana
0.228
-
 (6E)-8-oxogeranial isoform 3, pH 7, 22°C Amborella trichopoda
0.41
-
 (6E)-8-oxogeranial isoform 3, pH 7, 22°C Selaginella moellendorffii
3.421
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Digitalis lanata

Organism

Organism UniProt Comment Textmining
Amborella trichopoda
-
-
-
Arabidopsis thaliana
-
-
-
Catharanthus roseus K7WDL7
-
-
Coccomyxa subellipsoidea
-
-
-
Digitalis lanata
-
-
-
Digitalis purpurea
-
-
-
Selaginella moellendorffii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E)-8-oxogeranial + NADPH + H+
-
 Arabidopsis thaliana (S)-8-oxocitronellyl enol + NADP+
-
 ?
(6E)-8-oxogeranial + NADPH + H+
-
 Digitalis lanata (S)-8-oxocitronellyl enol + NADP+
-
 ?
(6E)-8-oxogeranial + NADPH + H+
-
 Digitalis purpurea (S)-8-oxocitronellyl enol + NADP+
-
 ?
(6E)-8-oxogeranial + NADPH + H+
-
 Selaginella moellendorffii (S)-8-oxocitronellyl enol + NADP+
-
 ?
(6E)-8-oxogeranial + NADPH + H+
-
 Catharanthus roseus (S)-8-oxocitronellyl enol + NADP+
-
 ?
(6E)-8-oxogeranial + NADPH + H+
-
 Amborella trichopoda (S)-8-oxocitronellyl enol + NADP+
-
 ?
(6E)-8-oxogeranial + NADPH + H+
-
 Coccomyxa subellipsoidea (S)-8-oxocitronellyl enol + NADP+
-
 ?
additional information enzyme additionally catalyzes the oxidation of progesterone, cf. EC 1.3.1.3 Arabidopsis thaliana ?
-
-
additional information enzyme additionally catalyzes the oxidation of progesterone, cf. EC 1.3.1.3 Digitalis lanata ?
-
-
additional information enzyme additionally catalyzes the oxidation of progesterone, cf. EC 1.3.1.3 Digitalis purpurea ?
-
-
additional information enzyme additionally catalyzes the oxidation of progesterone, cf. EC 1.3.1.3 Selaginella moellendorffii ?
-
-
additional information enzyme additionally catalyzes the oxidation of progesterone, cf. EC 1.3.1.3 Catharanthus roseus ?
-
-
additional information enzyme additionally catalyzes the oxidation of progesterone, cf. EC 1.3.1.3 Amborella trichopoda ?
-
-
additional information enzyme additionally catalyzes the oxidation of progesterone, cf. EC 1.3.1.3 Coccomyxa subellipsoidea ?
-
-

Synonyms

Synonyms Comment Organism
PRISE
-
 Arabidopsis thaliana
PRISE
-
 Digitalis lanata
PRISE
-
 Digitalis purpurea
PRISE
-
 Selaginella moellendorffii
PRISE
-
 Catharanthus roseus
PRISE
-
 Amborella trichopoda
PRISE
-
 Coccomyxa subellipsoidea
progesterone 5beta-reductase/iridoid synthase
-
 Arabidopsis thaliana
progesterone 5beta-reductase/iridoid synthase
-
 Digitalis lanata
progesterone 5beta-reductase/iridoid synthase
-
 Digitalis purpurea
progesterone 5beta-reductase/iridoid synthase
-
 Selaginella moellendorffii
progesterone 5beta-reductase/iridoid synthase
-
 Catharanthus roseus
progesterone 5beta-reductase/iridoid synthase
-
 Amborella trichopoda
progesterone 5beta-reductase/iridoid synthase
-
 Coccomyxa subellipsoidea

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.002
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Arabidopsis thaliana
0.006
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Selaginella moellendorffii
0.025
-
 (6E)-8-oxogeranial pH 7, 22°C Coccomyxa subellipsoidea
0.064
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Digitalis lanata
0.066
-
 (6E)-8-oxogeranial pH 7, 22°C Coccomyxa subellipsoidea
0.155
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Arabidopsis thaliana
0.321
-
 (6E)-8-oxogeranial isoform 3, pH 7, 22°C Amborella trichopoda
2.03
-
 (6E)-8-oxogeranial isoform 3, pH 7, 22°C Selaginella moellendorffii
5.84
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Catharanthus roseus
6.32
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Digitalis purpurea

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.019
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Digitalis lanata
0.308
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Arabidopsis thaliana
1.273
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Selaginella moellendorffii
1.41
-
 (6E)-8-oxogeranial isoform 3, pH 7, 22°C Amborella trichopoda
2.103
-
 (6E)-8-oxogeranial pH 7, 22°C Coccomyxa subellipsoidea
3.579
-
 (6E)-8-oxogeranial pH 7, 22°C Coccomyxa subellipsoidea
3.707
-
 (6E)-8-oxogeranial isoform 1, pH 7, 22°C Arabidopsis thaliana
4.95
-
 (6E)-8-oxogeranial isoform 3, pH 7, 22°C Selaginella moellendorffii
356.489
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Digitalis purpurea
688.739
-
 (6E)-8-oxogeranial isoform 2, pH 7, 22°C Catharanthus roseus