Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + reduced acceptor | Homo sapiens | - |
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
KIJ-265T cell | - |
Homo sapiens | - |
KIJ-308T cell | - |
Homo sapiens | - |
renal cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + reduced acceptor | - |
Homo sapiens | 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 28000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DIO1 | - |
Homo sapiens |
type 1 iodothyronine deiodinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme loss contributes to renal carcinogenesis | Homo sapiens |
physiological function | enzyme overexpression inhibits migration of renal cancer cells. Induction of DIO1 expression in KIJ265T cells leads to significantly decreased cellular proliferation and affects the expression of cell cycle genes, inhibiting the expression of genes that stimulate G1-to-S transition (e.g. cyclin E1) while stimulating the expression of cell cycle repressor E2F | Homo sapiens |