Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | - |
Homo sapiens | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | the catalytic cycle of ID-1 involves a ping-pong bisubstrate reaction in which the selenol form of the enzyme (ESeH) reacts with L-thyroxine to form a selenenyl iodide intermediate (ESeI) with release of the deiodinated compound 3,5,3'-triiodo-L-thyronine, and a subsequent reaction between the selenenyl iodide intermediate and possibly a thiol cofactor regenerates the selenol form | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ID-1 | - |
Homo sapiens |
type I iodothyronine deiodinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithioerythritol | - |
Homo sapiens |