Activating Compound | Comment | Organism | Structure |
---|---|---|---|
carbobenzoxy-L-leucyl-L-leucyl-L-leucinal | MG132, proteasome inhibitor, increases type 2 deiodinase | Rattus norvegicus | |
forskolin | increases mRNA expression and type 2 deiodinase activity, hypoxia stimulates forskolin induces activation of type 2 deiodinase | Rattus norvegicus | |
additional information | hypoxia activates type 2 deiodinase by a posttranslational mechanism, glucose depletion decrased hypoxia induced type 2 deiodinase activation, agents promoting hypoxia like desferrioxamine, dimethyloxalylglycine, diethylsuccinatecobalt chloride activate type 2 deiodinase | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3',5,5'-tetraiodo-L-thyronine | hypoxia has no effect on inhibition of T4 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | cell culture | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0000000003 | - |
medium alone | Rattus norvegicus |
0.0000000006 | - |
hypoxia | Rattus norvegicus |
0.000000025 | - |
in presence of carbobenzoxy-L-leucyl-L-leucyl-L-leucinal | Rattus norvegicus |
0.00000003 | - |
10 micromol forskolin | Rattus norvegicus |
0.00000009 | - |
10 micromol forskolin and hypoxia | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | addition of I125 labelled T4 to measure the production of T3, using paper chromatography | Rattus norvegicus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 2 deiodinase | - |
Rattus norvegicus |