Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one | aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
(2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one | aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one | aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one | aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid | aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one | aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodo-L-thyronine + AH2 | - |
Rattus norvegicus | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | - |
Rattus norvegicus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
pH 7.4, 37°C | Rattus norvegicus | (2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one | |
0.001 | - |
pH 7.4, 37°C | Rattus norvegicus | (2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one | |
0.001 | - |
pH 7.4, 37°C | Rattus norvegicus | (2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one | |
0.005 | - |
pH 7.4, 37°C | Rattus norvegicus | (4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid | |
0.008 | - |
pH 7.4, 37°C | Rattus norvegicus | 2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one | |
0.01 | - |
pH 7.4, 37°C | Rattus norvegicus | (2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one |