Organism | UniProt | Comment | Textmining |
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synthetic construct | - |
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General Information | Comment | Organism |
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physiological function | the heterodinucleating ligand LH2, i.e. (E)-3-(((2,7-di-tert-butyl-9,9-dimethyl-5-((pyridin-2-ylmethylene)amino)-9H-xanthen-4-yl)amino)methyl)benzene-1,2-diol functions as functional model of the bimetallic active site found in Mo-Cu carbon monoxide dehydrogenase. Treatment of LH2 with either Cu(I) or M(VI) (M = Mo, W) sources leads to the site-selective incorporation of the respective metals. The incorporation of both Mo(VI) and Cu(I) into L forms a highly reactive heterobimetallic complex [MoVIO3CuI(L)](NEt4)2, that triggers oxidation reactivity, in which a nucleophilic Mo(VI) trioxo attacks Cu(I)-bound imine. The major product of the reaction is a molybdenum(VI) complex [Mo(L')O2](NEt4) coordinated by a modified ligand L' that contains a new C-O bond in place of the imine functionality | synthetic construct |