Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-aminophenyl arsenoxide | 0.1 mM, 92% loss of activity in presence of pyruvate and CoA. Controls lacking pyruvate and/or coenzyme A, but containing H2NPhAsO, retain nearly all their pyruvate dehydrogenase complex activity. The arsenoxide forms a stable cyclic dithiolarsinite with reduced lipoic acid on E2 which is generated by pyruvate and coenzyme A according. Pyruvate dehydrogenase complex activity can be recovered to 78% within 2 min following the addition of 2,3-dithiopropanol | Escherichia coli | |
bromoacetylaniline arsenoxide | BrCH2CONHPhAsO, 0.1 mM, 100% loss of activity in presence of pyruvate and CoA. The initial reaction of the bifunctional reagent occurs on E2 via the R-AsO moiety and results in the rapid loss in pyruvate dehydrogenase complex activity. Addition of 2,3-dithiopropanol fails to regenerate the complex activity and E3 activity | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P06959 | P06959 i.e. dihydrolipoyllysine-residue acetyltransferase component | - |
Synonyms | Comment | Organism |
---|---|---|
AceF | - |
Escherichia coli |