Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin | potent, non-competitive tyrosinase inhibitor, 68.3% inhibition at 0.8 mM | Agaricus bisporus | |
3-(3-hydroxyphenyl)-2H-chromen-2-one | 19.3% inhibition at 0.8 mM | Agaricus bisporus | |
6-hydroxy-3-(4'-hydroxyphenyl)coumarin | 26.7% inhibition at 0.8 mM | Agaricus bisporus | |
7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-2-one | 9.6% inhibition at 0.8 mM | Agaricus bisporus | |
umbelliferone | - |
Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.1 | - |
IC50 above 0.1 mM, in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C | Agaricus bisporus | 7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-2-one | |
0.27 | - |
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C | Agaricus bisporus | 3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin | |
0.42 | - |
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C | Agaricus bisporus | umbelliferone | |
1.567 | - |
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C | Agaricus bisporus | 6-hydroxy-3-(4'-hydroxyphenyl)coumarin | |
3.68 | - |
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C | Agaricus bisporus | 3-(3-hydroxyphenyl)-2H-chromen-2-one |