Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-cyclopentyl-1-hydroxy-2-oxohydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
1-dodecyl-1-hydroxy-2-oxohydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
1-hydroxy-2-oxo-1-phenylhydrazine | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
4-[[hydroxy(nitroso)amino]methyl]phenol | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied | Agaricus bisporus | |
benzohydroxamic acid | is known to inhibit tyrosinase by chelating with copper. Completely independent of pH | Agaricus bisporus | |
benzoic acid | is known to inhibit tyrosinase by chelating with copper. Acts in a similar manner to 1-hydroxy-2-oxo-1-phenylhydrazine | Agaricus bisporus | |
kojic acid | is known to inhibit tyrosinase by chelating with copper. Shows only slight pH-dependence of tyrosinase inhibition | Agaricus bisporus | |
tropolone | is known to inhibit tyrosinase by chelating with copper. Shows only slight pH-dependence of tyrosinase inhibition | Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Agaricus bisporus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
6800 | - |
- |
Agaricus bisporus |
Synonyms | Comment | Organism |
---|---|---|
polyphenol oxidase | - |
Agaricus bisporus |
tyrosinase | - |
Agaricus bisporus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
relative acitvity at pH 6.8, the activity is almost the same in the range pH 5.5-8.0 | Agaricus bisporus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 9 | the activity of mushrom tyrosinase is studied in this pH range | Agaricus bisporus |
5.5 | 8 | inhibition of the diphenolase activity of mushroom tyrosinase over the pH range of 5.5-8.0 is studied. The observed inhibitory activity at pH 6.8. and 5.8 is approximately 10times and 100times greater than at pH 7.8 | Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
1-hydroxy-2-oxo-1-phenylhydrazine displays competitive inhibition at pH 6.8 and 5.8, all the other N-substituted N-nitrosohydroxylamines show a different type of inhibition at pH 6.8. and 5.8 | Agaricus bisporus | additional information | |
0.000075 | - |
at pH 5.8 | Agaricus bisporus | 1-cyclopentyl-1-hydroxy-2-oxohydrazine | |
0.00013 | - |
at pH 5.8 | Agaricus bisporus | 1-hydroxy-2-oxo-1-phenylhydrazine | |
0.00026 | - |
at pH 5.8 | Agaricus bisporus | 1-dodecyl-1-hydroxy-2-oxohydrazine | |
0.0006 | - |
at pH 6.8 | Agaricus bisporus | 1-cyclopentyl-1-hydroxy-2-oxohydrazine | |
0.0011 | - |
at pH 5.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]phenol | |
0.0011 | - |
at pH 6.8 | Agaricus bisporus | 1-hydroxy-2-oxo-1-phenylhydrazine | |
0.0022 | - |
at pH 6.8 | Agaricus bisporus | 1-dodecyl-1-hydroxy-2-oxohydrazine | |
0.0027 | - |
at pH 5.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol | |
0.0062 | - |
at pH 5.8 | Agaricus bisporus | 1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine | |
0.0137 | - |
at pH 6.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]phenol | |
0.0238 | - |
at pH 6.8 | Agaricus bisporus | 4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol | |
0.046 | - |
- |
Agaricus bisporus | 1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine |