Literature summary for 1.14.13.250 extracted from

Wang, J.; Wang, X.; Ouyang, Q.; Liu, W.; Shan, J.; Tan, H.; Li, X.; Chen, G.
N-Nitrosation mechanism catalyzed by non-heme iron-containing enzyme SznF involving intramolecular oxidative rearrangement (2021), Inorg. Chem., 60, 7719-7731 .

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces achromogenes subsp. streptozoticus	A0A411MR89	-	-

General Information

General Information	Comment	Organism
metabolism	mechanism for the N-nitrosation reaction. A four-electron oxidation process is accomplished through a series of complicated electron transferring between the iron center and substrate to bypass the high-valent FeIV=O species. In the catalytic reaction pathway, the O2 binds to the iron center and attacks on the substrate to form the peroxo bridge intermediate by obtaining two electrons from the substrate exclusively. Instead of cleaving the peroxo bridge, the Cepsilon-Nomega bond of the substrate is homolytically cleaved first to form a carbocation intermediate, which polarizes the peroxo bridge and promotes its heterolysis. After O-O bond cleavage, the following reaction steps proceed effortlessly so that the N-nitrosation is accomplished without NO exchange among reaction species	Streptomyces achromogenes subsp. streptozoticus

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Release 2023.1 (January 2023)