Literature summary for 1.14.13.225 extracted from

McGarry, D.J.; Armstrong, G.; Castino, G.; Mason, S.; Clark, W.; Shaw, R.; McGarry, L.; Blyth, K.; Olson, M.F.
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours (2021), Cancer Lett., 519, 226-236 .

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Application

Application	Comment	Organism
medicine	elevated MICAL1 gene expression is observed in invasive breast cancer samples from human patients relative to normal tissue, while MICAL1 amplification or point mutations are associated with reduced progression free survival	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8TDZ2	isoform MICAL1, cf. EC 1.6.3.1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MICAL1	cf. EC 1.6.3.1	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	MICAL1 gene disruption in MDA-MB-231 cells knocks out protein expression, which affects F-actin organization, cell size and motility. MICAL1 deletion significantly affects the expression of over 700 genes, with the majority being reduced in their expression levels. Receptor regulator activity is the most significant negatively enriched molecular function gene set. MICAL1 deletion on is also associated with changes in the expression of several serum-response factor regulated genes. MICAL1 disruption attenuates breast cancer tumour growth in vivo	Homo sapiens

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Release 2023.1 (January 2023)