Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces coeruleorubidus | A0A3B6UEU3 | - |
- |
General Information | Comment | Organism |
---|---|---|
metabolism | isonitrile can only be formed through two consecutive catalytic cycles that both use one molecule of dioxygen and 2-oxoglutarate. In both cycles the active species is an iron(IV)-oxo species that in the first reaction cycle reacts through two consecutive hydrogen atom abstraction steps, first from the N-H group and thereafter from the C-H group to desaturate the NH-CH2 bond. The electronic configurations along that pathway implicate an initial hydride transfer followed by proton transfer. A second catalytic cycle of the reaction of iron(IV)-oxo with desaturated substrate starts with hydrogen atom abstraction followed by decarboxylation to give isonitrile directly | Streptomyces coeruleorubidus |