Cloned (Comment) | Organism |
---|---|
expression in insect cells using a baculovirus vector | Homo sapiens |
expression in various human tissues | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required, Km: 0.001-0.005 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
2 * 88000 or 97000 SDS-PAGE, recombinant enzymes: isoform 2, possibly two forms are due to variation in the glycosylation of enzymes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen + 2-oxoglutarate + O2 | Homo sapiens | enzyme required during collagen biosynthesis | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
collagen + 2-oxoglutarate + O2 | Homo sapiens | influence the integrity and stability of collagen | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00469 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
side-chain modification | hydroxylation of lysyl residue in -X-Lys-Gly | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | existence of isoforms | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen + 2-oxoglutarate + O2 | enzyme required during collagen biosynthesis | Homo sapiens | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
collagen + 2-oxoglutarate + O2 | influence the integrity and stability of collagen | Homo sapiens | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
peptidyl-L-lysine + 2-oxoglutarate + O2 | synthetic peptides | Homo sapiens | peptidyl-5-hydroxy-L-lysine + succinate + CO2 | hydroxy-L-lysine | ? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 88000 or 97000 SDS-PAGE, recombinant enzymes: isoform 2, possibly two forms are due to variation in the glycosylation of enzymes | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
lysyl hydroxylase | lysyl hydroxylase 1 and 2 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | required | Homo sapiens |