Literature summary for 1.14.11.29 extracted from

Chong, M.; Toh, L.; Tumber, A.; Chan, Y.; Chan, M.; Abboud, M.; Schofield, C.; Yeoh, K.
Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (2021), Med. Chem. Res., 30, 977-986 .

No PubMed abstract available

Search for more literature for 1.14.11.29

Cloned(Commentary)

Cloned (Comment)	Organism
expression of catalytic domain, residues 181-426	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-[(1,3-benzoxazol-2-yl)carbamoyl]propanoic acid	-	Homo sapiens
3-[(5-chloro-1,3-benzoxazol-2-yl)carbamoyl]propanoic acid	-	Homo sapiens
FG-4592	i.e. roxadustat	Homo sapiens
additional information	compounds with a 3-carbamoylpropanoic acids-containing benzoxazole moiety are inhibitors of PHD-2. However, neither the acids nor their respective ethyl esters upregulate HIF-1alpha levels in cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9GZT9	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00132	-	pH 7.8, temperature not specified in the publication	Homo sapiens	3-[(5-chloro-1,3-benzoxazol-2-yl)carbamoyl]propanoic acid
0.00221	-	pH 7.8, temperature not specified in the publication	Homo sapiens	FG-4592
0.00224	-	pH 7.8, temperature not specified in the publication	Homo sapiens	3-[(1,3-benzoxazol-2-yl)carbamoyl]propanoic acid

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Release 2023.1 (January 2023)