Literature summary for 1.14.11.29 extracted from

Poloznikov, A.A.; Nikulin, S.V.; Zakhariants, A.A.; Khristichenko, A.Y.; Hushpulian, D.M.; Gazizov, I.N.; Tishkov, V.I.; Gazaryan, I.G.
''Branched Tail'' oxyquinoline inhibitors of HIF prolyl hydroxylase early evaluation of toxicity and metabolism using liver-on-a-chip (2019), Drug Metab. Lett., 13, 45-52 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
adaptaquin	EC50 of ca 2 mM in HIF1 ODD-luc fusion reporter assay	Homo sapiens
N-[(3,4-dimethoxyphenyl)(8-hydroxyquinolin-7-yl)methyl]-2-phenylacetamide	optimized adaptaquin analog, shows no toxicity up to a 100fold increased range over EC50. The drug is ismetabolized by CYP3A4 and CYP2B6	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hepa-RG cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)