Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q91UZ4 | C57BL/6 mice | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | - |
Mus musculus | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHD3 | - |
Mus musculus |
prolyl 4-hydroxylase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression of prolyl 4-hydroxylase domain protein 3 (PHD3) increases under hypoxia. Fibrosis improves when PHD3 is overexpressed | up |
General Information | Comment | Organism |
---|---|---|
drug target | prolyl 4-hydroxylase domain protein 3 (PHD3) overexpression has therapeutic potential in treatment of obstructive sleep apnea and intermittent hypoxia induced cardiovascular fibrosis | Mus musculus |