Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | Homo sapiens | PHD enzymes hydroxylates HIF-alpha at prolyl residues present in the transcriptional activation domain N-TAD | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | PHD enzymes hydroxylates HIF-alpha at prolyl residues present in the transcriptional activation domain N-TAD | Homo sapiens | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHD | - |
Homo sapiens |
PHD2 | - |
Homo sapiens |
PHD3 | - |
Homo sapiens |
prolyl hydroxylase domain | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | HIF protein stability is controlled by the oxygen sensing prolyl hydroxylase domain enzymes. Hypoxia-induced HIF signalling, mathematical modelling of the pathway, temporal dynamics of the HIF response to hypoxia, and molecular interaction map for the HIF network, overview. The hypoxia inducible factor is switched on and promotes adaptation to hypoxia by upregulatinggenes involved in angiogenesis, erythropoiesis and glycolysis | Homo sapiens |
additional information | PHD has a higher affinity for oxygen than FIH, EC 1.14.11.30 | Homo sapiens |
physiological function | HIF transcriptional activity is controlled by the asparaginyl hydroxylase factor inhibiting HIF-1, FIH | Homo sapiens |